CD8+ T cells infiltrating into bile ducts in biliary atresia do not appear to function as cytotoxic T cells: A clinicopathological analysis

Abul Faiz Kabir Uddin Ahmed, Haruo Ohtani, Masaki Nio, Nobuo Funaki, Satoru Shimaoka, Hiroshi Nagura, Ryoji Ohi

研究成果: Article査読

46 被引用数 (Scopus)

抄録

It is speculated that immune mechanisms are involved in bile duct damage in biliary atresia (BA), as in primary biliary cirrhosis (PBC). In BA, however, no reports have described the in situ distribution of cytotoxic T lymphocytes (CTLs) using specific markers, nor has the clinical association been clarified. The present study describes the immunohistochemical distribution of CD8+ T cells and the relevant markers [perforin, granzyme B, FasL (CD95L)] in 47 cases of BA operated upon at days 12-79. The results were compared with those of PBC. In BA, CD8+ T cells infiltrated bile ducts in a way similar to that observed in PBC. However, in sharp contrast to PBC, none of the inflammatory cells infiltrating into the bile ducts in BA expressed cytotoxic markers such as perforin, granzyme B, or Fas ligand (FasL). Clinical follow-up of patients with BA revealed that a greater degree of infiltration of bile ducts by CD8+ T cells is associated with better liver function. Taken together, these data suggest the absence of direct CTL activity against bile ducts in BA in the postnatal period.

本文言語English
ページ(範囲)383-389
ページ数7
ジャーナルJournal of Pathology
193
3
DOI
出版ステータスPublished - 2001 4 2

ASJC Scopus subject areas

  • 病理学および法医学

フィンガープリント

「CD8<sup>+</sup> T cells infiltrating into bile ducts in biliary atresia do not appear to function as cytotoxic T cells: A clinicopathological analysis」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル