Caught in self-interaction: Evolutionary and functional mechanisms of protein homooligomerization

Kosuke Hashimoto, Hafumi Nishi, Stephen Bryant, Anna R. Panchenko

研究成果: Article査読

69 被引用数 (Scopus)

抄録

Many soluble and membrane proteins form homooligomeric complexes in a cell which are responsible for the diversity and specificity of many pathways, may mediate and regulate gene expression, activity of enzymes, ion channels, receptors, and cell adhesion processes. The evolutionary and physical mechanisms of oligomerization are very diverse and its general principles have not yet been formulated. Homooligomeric states may be conserved within certain protein subfamilies and might be important in providing specificity to certain substrates while minimizing interactions with other unwanted partners. Moreover, recent studies have led to a greater awareness that transitions between different oligomeric states may regulate protein activity and provide the switch between different pathways. In this paper we summarize the biological importance of homooligomeric assemblies, physico-chemical properties of their interfaces, experimental and computational methods for their identification and prediction. We particularly focus on homooligomer evolution and describe the mechanisms to develop new specificities through the formation of different homooligomeric complexes. Finally, we discuss the possible role of oligomeric transitions in the regulation of protein activity and compile a set of experimental examples with such regulatory mechanisms.

本文言語English
論文番号035007
ジャーナルPhysical Biology
8
3
DOI
出版ステータスPublished - 2011 6
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 分子生物学
  • 細胞生物学

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