Catalytic Depolymerization of Chitin with Retention of N-Acetyl Group

Mizuho Yabushita, Hirokazu Kobayashi, Kyoichi Kuroki, Shogo Ito, Atsushi Fukuoka

研究成果: Article査読

45 被引用数 (Scopus)

抄録

Chitin, a polymer of N-acetylglucosamine units with β-1,4-glycosidic linkages, is the most abundant marine biomass. Chitin monomers containing N-acetyl groups are useful precursors to various fine chemicals and medicines. However, the selective conversion of robust chitin to N-acetylated monomers currently requires a large excess of acid or a long reaction time, which limits its application. We demonstrate a fast catalytic transformation of chitin to monomers with retention of N-acetyl groups by combining mechanochemistry and homogeneous catalysis. Mechanical-force-assisted depolymerization of chitin with a catalytic amount of H2SO4 gave soluble short-chain oligomers. Subsequent hydrolysis of the ball-milled sample provided N-acetylglucosamine in 53 % yield, and methanolysis afforded 1-O-methyl-N-acetylglucosamine in yields of up to 70 %. Our process can greatly reduce the use of acid compared to the conventional process.

本文言語English
ページ(範囲)3760-3763
ページ数4
ジャーナルChemSusChem
8
22
DOI
出版ステータスPublished - 2015 11 23
外部発表はい

ASJC Scopus subject areas

  • 環境化学
  • 化学工学(全般)
  • 材料科学(全般)
  • エネルギー(全般)

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