Ca2+, calmodulin-dependent phosphorylation of glycogen synthase by a brain protein kinase

Takafumi Iwasa, Kohji Fukunaga, Hideyuki Yamamoto, Etsuro Tanaka, Eishichi Miyamoto

研究成果: Article査読

15 被引用数 (Scopus)

抄録

A Ca2+, calmodulin-dependent protein kinase from brain with a Mr of 640 000 is capable of phosphorylating glycogen synthase from skeletal muscle. The reaction was inhibited by the addition of 1 mM EGTA and 50 μM trifluoperazine, but not by protein kinase inhibitor and heparin. The amount of phosphate incorporated into glycogen synthase was 1.4 mol/mol subunit. The phosphorylation sites of glycogen synthase were cyanogen bromide-treated peptides CB-1 and CB-2 and only the seryl residue was phosphorylated.

本文言語English
ページ(範囲)28-32
ページ数5
ジャーナルFEBS Letters
161
1
DOI
出版ステータスPublished - 1983 9月 5
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 構造生物学
  • 生化学
  • 分子生物学
  • 遺伝学
  • 細胞生物学

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