Cav2.3 (α1E) Ca2+ channel participates in the control of sperm function

Yu Sakata, Hironao Saegusa, Shuqin Zong, Makoto Osanai, Takayuki Murakoshi, Yasufumi Shimizu, Tetsuo Noda, Takeshi Aso, Tsutomu Tanabe

研究成果: Article査読

42 被引用数 (Scopus)

抄録

To know the function of the Ca2+ channel containing α12.3 (α1E) subunit (Cav2.3 channel) in spermatozoa, we analyzed Ca2+ transients and sperm motility using a mouse strain lacking Cav2.3 channel. The averaged rising rates of Ca2+ transients induced by α-D-mannose-bovine serum albumin in the head region of Cav2.3-/- sperm were significantly lower than those of Cav2.3+/+ sperm. A computer-assisted sperm motility assay revealed that straight-line velocity and linearity were greater in Cav2.3-/- sperm than those in Cav2.3+/+ sperm. These results suggest that the Cav2.3 channel plays some roles in Ca2+ transients and the control of flagellar movement.

本文言語English
ページ(範囲)229-233
ページ数5
ジャーナルFEBS Letters
516
1-3
DOI
出版ステータスPublished - 2002 4 10

ASJC Scopus subject areas

  • Biophysics
  • Structural Biology
  • Biochemistry
  • Molecular Biology
  • Genetics
  • Cell Biology

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