Cardiac Angiotensin Converting Enzyme and Endothelin Receptor in Rats with Chronic Myocardial Infarction

Masahiro Kohzuki, Masayuki Kanazawa, Kazunori Yoshida, Masahiro Kamimoto, Xue Min Wu, Zhong Li Jiang, Minoru Yasujima, Keishi Abe, Colin I. Johnston, Tokutaro Sato

研究成果: Article査読

8 被引用数 (Scopus)

抄録

To ascertain the pathophysiological roles of the renin-angiotensin system and endothelin in heart failure and cardiac hypertrophy, we assessed changes in cardiac angiotensin converting enzyme (ACE) and endothelin-1 (ET-1) receptor using rats in which myocardial infarction was induced by left coronary ligation. The animals were decapitated 1 or 8 months after the operation. Cardiac ACE and ET-1 receptor were quantified by computerized in vitro autoradiography using 125I-MK351A (a lisinopril derivative) and 125I-ET-1. One month after myocardial infarction, cardiac weight and plasma atrial natriuretic peptide had increased in rats with infarction, compared to sham-operated controls, indicating the presence of chronic left ventricular dysfunction, although exchangeable body sodium and plasma renin activity were unchanged. Cardiac ACE increased markedly in the infarcted area and moderately in hypertrophied myocardium without any change in affinity compared to sham-operated rats. On the other hand, there was no change in cardiac ET-1 receptors in infarcted rats. The same results were found even at 8 months after myocardial infarction. The present study indicates that cardiac ACE may participate in tissue repair at the site of myocardial infarction and may also play a role in the pathophysiology of cardiac hypertrophy in rats with chronic heart failure. However, the present results do not reveal whether ET-1 receptor participates in the pathophysiology of cardiac hypertrophy in this model.

本文言語English
ページ(範囲)972-980
ページ数9
ジャーナルJAPANESE CIRCULATION JOURNAL
60
12
DOI
出版ステータスPublished - 1996

ASJC Scopus subject areas

  • 生理学
  • 循環器および心血管医学

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