Carbon ion radiation therapy improves the prognosis of unresectable adult bone and soft-tissue sarcoma of the head and neck

Keiichi Jingu, Hirohiko Tsujii, Jun Etsu Mizoe, Azusa Hasegawa, Hiroki Bessho, Ryo Takagi, Takamichi Morikawa, Morio Tonogi, Hiroshi Tsuji, Tadashi Kamada, Shogo Yamada

研究成果: Article

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Purpose: To evaluate the safety and efficacy of carbon ion radiotherapy (C-ion RT) with 70.4 GyE for unresectable bone and soft-tissue sarcoma of the adult head and neck. Methods and Materials: Twenty-seven patients (mean age, 46.2 years) were enrolled in this prospective study on C-ion RT with 70.4 GyE/16 fractions (fr) between April 2001 and February 2008. The primary end points were acute and late reactions of normal tissues, local control rate, and overall survival rate. The secondary end point was efficacy of the treatment in comparison to historical results with 57.6 or 64.0 GyE/16 fr. Results: The 3-year local control rate and overall survival rate for all patients were 91.8% (95% confidence interval [CI] = 81.0-100%) and 74.1% (95% CI = 57.5-90.6%), respectively. Acute reaction of Grade 3 or more was observed in only 1 patient. With regard to late reactions, visual loss was observed in 1 patient and a Grade 3 reaction of the maxillary bone was observed in 4 patients. A comparison with historical results revealed that the local control rate with 70.4 GyE was significantly higher than that with 57.6 or 64.0 GyE (3-year, 91.8% vs. 23.6%, p < 0.0001). Furthermore, the overall survival with 70.4 GyE tended to be higher than that with 57.6 or 64.0 GyE (3-year, 74.1% vs. 42.9%, p = 0.09). Conclusion: C-ion RT with 70.4 GyE/16 fr for bone and soft-tissue sarcoma of the adult head and neck appears to be effective with acceptable toxicities in comparison to conventional RT and C-ion RT with lower doses.

元の言語English
ページ(範囲)2125-2131
ページ数7
ジャーナルInternational Journal of Radiation Oncology Biology Physics
82
発行部数5
DOI
出版物ステータスPublished - 2012 4 1

ASJC Scopus subject areas

  • Radiation
  • Oncology
  • Radiology Nuclear Medicine and imaging
  • Cancer Research

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    Jingu, K., Tsujii, H., Mizoe, J. E., Hasegawa, A., Bessho, H., Takagi, R., Morikawa, T., Tonogi, M., Tsuji, H., Kamada, T., & Yamada, S. (2012). Carbon ion radiation therapy improves the prognosis of unresectable adult bone and soft-tissue sarcoma of the head and neck. International Journal of Radiation Oncology Biology Physics, 82(5), 2125-2131. https://doi.org/10.1016/j.ijrobp.2010.08.043