Carbamate as an accelerating group in intermolecular Pauson-Khand reaction

Shota Asano, Kaori Itto-Nakama, Hirokazu Arimoto

研究成果: Article

抜粋

The Pauson-Khand reaction (PKR) is a powerful means for the construction of cyclopentenones. However, its applications have been limited to the intramolecular version of this reaction because poor yield and regioselectivity are often the major problems in intermolecular PKR. Here we describe that a carbamate moiety in alkene substrate accelerates this intermolecular PKR. The reaction of N-4-dimethylaminophenyl O-allyl carbamate with alkyne-cobalt complex gave cyclopentenones in high yield (up to 90%) and regioselectivity (>9:1).

元の言語English
記事番号151974
ジャーナルTetrahedron Letters
61
発行部数24
DOI
出版物ステータスPublished - 2020 6 11

ASJC Scopus subject areas

  • Biochemistry
  • Drug Discovery
  • Organic Chemistry

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