TY - JOUR
T1 - Calcium Channel Blockers Reverse the Sustained Elevation of Blood Pressure Induced by Chronic Infusion of Endothelin in Conscious Rats
AU - Yasujima, Minoru
AU - Abe, Keishi
AU - Kanazawa, Masayuki
AU - Yoshida, Kazunori
AU - Sato, Makito
AU - Takeuchi, Kazuhisa
AU - Tsunoda, Kazuo
AU - Kudo, Kei
AU - Kohzuki, Masahiro
AU - Omata, Ken
AU - Yabe, Tamami
AU - Hlwatari, Masao
AU - Sato, Tokutaro
AU - Yoshinaga, Kaoru
PY - 1990
Y1 - 1990
N2 - YASUJIMA, M., ABE, K., KANAZAWA, M., YOSHIDA, K., SATO, M., TAKEUCHI, K., TSUNODA, K., KUDO, K., KOHZUKI, M., OMATA, K., YABE, T., HIWATARI, M., SATO, T. and YOSHINAGA, K. Calcium Channel Blockers Reverse the Sustained Elevation of Blood Pressure Induced by Chronic Infusion of Endothelin in Conscious Rats. Tohoku J. Exp. Med., 1990, 160 (2), 157-165 — To determine whether endothelin could act as a circulating hormone in the regulation of blood pressure and sodium-water excretion, we assessed the chronic effects of synthetic endothelin on systolic blood pressure, urine volume and urinary sodium excretion in conscious rats, and also evaluated the effects of benidipine or nilvadipine, newly developed calcium channel blockers, in rats infused chronically with synthetic endothelin. Continuous infusion of endothelin at a rate of 60 μg/kg/day into the jugular vein via osmotic minipumps induced a significant increase in systolic blood pressure, but did not induce any significant changes in urine volume and urinary sodium excretion, compared to those in vehicle-infused rats. On the contrary, the infusion of endothelin at a rate of 60 μg/kg/day did not induce any significant changes in systolic blood pressure, urine volume and urinary sodium excretion, compared to those in vehicle-infused rats. When 6 mg/kg/day of benidipine or 10 mg/kg/day of nilvadipine was administered simultaneously with 60 μg/kg/day of endothelin, the systolic blood pressure rose on Day I to only 137.0±2.4 mmHg (p<0.05) and 119.7±5.9 mmHg (p<0.05) compared to the rise to 163.8±4.7 mmHg when endothelin alone was infused. The antihypertensive effect of benidipine or nilvadipine was sustained for the entire experimental period and was not associated with any significant changes in urine volume and urinary sodium excretion. The present results suggest that endothelin can act as a circulating hormone and might be involved in the regulation of blood pressure. In addition, they clearly demonstrate that the calcium channel blockers attenuate the elevation of blood pressure induced by endothelin, although the exact mechanisms whereby these drugs could interact remain to be determined. —endothelin; calcium channel blockers; blood pressure regulation; conscious rats.
AB - YASUJIMA, M., ABE, K., KANAZAWA, M., YOSHIDA, K., SATO, M., TAKEUCHI, K., TSUNODA, K., KUDO, K., KOHZUKI, M., OMATA, K., YABE, T., HIWATARI, M., SATO, T. and YOSHINAGA, K. Calcium Channel Blockers Reverse the Sustained Elevation of Blood Pressure Induced by Chronic Infusion of Endothelin in Conscious Rats. Tohoku J. Exp. Med., 1990, 160 (2), 157-165 — To determine whether endothelin could act as a circulating hormone in the regulation of blood pressure and sodium-water excretion, we assessed the chronic effects of synthetic endothelin on systolic blood pressure, urine volume and urinary sodium excretion in conscious rats, and also evaluated the effects of benidipine or nilvadipine, newly developed calcium channel blockers, in rats infused chronically with synthetic endothelin. Continuous infusion of endothelin at a rate of 60 μg/kg/day into the jugular vein via osmotic minipumps induced a significant increase in systolic blood pressure, but did not induce any significant changes in urine volume and urinary sodium excretion, compared to those in vehicle-infused rats. On the contrary, the infusion of endothelin at a rate of 60 μg/kg/day did not induce any significant changes in systolic blood pressure, urine volume and urinary sodium excretion, compared to those in vehicle-infused rats. When 6 mg/kg/day of benidipine or 10 mg/kg/day of nilvadipine was administered simultaneously with 60 μg/kg/day of endothelin, the systolic blood pressure rose on Day I to only 137.0±2.4 mmHg (p<0.05) and 119.7±5.9 mmHg (p<0.05) compared to the rise to 163.8±4.7 mmHg when endothelin alone was infused. The antihypertensive effect of benidipine or nilvadipine was sustained for the entire experimental period and was not associated with any significant changes in urine volume and urinary sodium excretion. The present results suggest that endothelin can act as a circulating hormone and might be involved in the regulation of blood pressure. In addition, they clearly demonstrate that the calcium channel blockers attenuate the elevation of blood pressure induced by endothelin, although the exact mechanisms whereby these drugs could interact remain to be determined. —endothelin; calcium channel blockers; blood pressure regulation; conscious rats.
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U2 - 10.1620/tjem.160.157
DO - 10.1620/tjem.160.157
M3 - Article
C2 - 2191473
AN - SCOPUS:0025042661
VL - 160
SP - 157
EP - 165
JO - Tohoku Journal of Experimental Medicine
JF - Tohoku Journal of Experimental Medicine
SN - 0040-8727
IS - 2
ER -