Caenorhabditis elegans reticulon interacts with RME-1 during embryogenesis

Jun Iwahashi, Ichiro Kawasaki, Yuji Kohara, Keiko Gengyo-Ando, Shohei Mitani, Yasumi Ohshima, Nobuyuki Hamada, Koyu Hara, Takahito Kashiwagi, Tetsuya Toyoda

研究成果: Article査読

33 被引用数 (Scopus)

抄録

Reticulon (RTN) family proteins are localized in the endoplasmic reticulum (ER). At least four different RTN genes have been identified in mammals, but in most cases, the functions of the encoded proteins except mammalian RTN4-A and RTN4-B are unknown. Each RTN gene produces 1-3 proteins by different promoters and alternative splicing. In Caenorhabditis elegans, there is a single gene (rtn gene) encoding three reticulon proteins, nRTN-A, B, and C. mRNA of nRTN-C is expressed in germ cells and embryos. However, nRTN-C protein is only expressed during embryogenesis and rapidly disappears after hatch. By yeast two-hybrid screening, two clones encoding the same C-terminal region of RME-1, a protein functioning in the endocytic recycling, were isolated. These findings suggest that nRTN-C functions in the endocytic pathway during embryogenesis.

本文言語English
ページ(範囲)698-704
ページ数7
ジャーナルBiochemical and biophysical research communications
293
2
DOI
出版ステータスPublished - 2002 1 1
外部発表はい

ASJC Scopus subject areas

  • 生物理学
  • 生化学
  • 分子生物学
  • 細胞生物学

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