Bruchpilot, A synaptic active zone protein for anesthesia-resistant memory

Stephan Knapek, Stephan Sigrist, Hiromu Tanimoto

研究成果: Article査読

42 被引用数 (Scopus)

抄録

In Drosophila, aversive associative memory of an odor consists of heterogeneous components with different stabilities. Here we report that Bruchpilot (Brp), a ubiquitous presynaptic active zone protein, is required for olfactory memory. Brp was shown before to facilitate efficient vesicle release, particularly at low stimulation frequencies. Transgenic knockdown in the Kenyon cells of the mushroom body, the second-order olfactory interneurons, revealed that Brp is required for olfactory memory. We further demonstrate that Brp in the Kenyon cells preferentially functions for anesthesia-resistant memory. Another presynaptic protein, Synapsin, was shown previously to be required selectively for the labile anesthesia-sensitive memory, which is less affected in brp knockdown. Thus, consolidated and labile components of aversive olfactory memory can be dissociated by the function of different presynaptic proteins.

本文言語English
ページ(範囲)3453-3458
ページ数6
ジャーナルJournal of Neuroscience
31
9
DOI
出版ステータスPublished - 2011 3 2
外部発表はい

ASJC Scopus subject areas

  • Neuroscience(all)

フィンガープリント 「Bruchpilot, A synaptic active zone protein for anesthesia-resistant memory」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル