Brain-derived neurotrophic factor gene polymorphisms and Alzheimer's disease

S. Matsushita, H. Arai, T. Matsui, T. Yuzuriha, K. Urakami, T. Masaki, S. Higuchi

研究成果: Article査読

78 被引用数 (Scopus)

抄録

Several lines of evidence have made brain-derived neurotrophic factor (BDNF) an important candidate gene conferring risk for Alzheimer's disease (AD). Recently, three studies reported an association between two single-nucleotide polymorphisms (SNP) - i.e., C270T and G196A - in the BDNF gene and AD. This attempt to confirm these associations in a larger AD sample included examination of the linkage disequilibrium of these two SNPs. Comparison of 487 Japanese AD subjects with 471 cognitively normal elderly controls showed higher frequencies of the G allele (60.5 vs. 55.5%, p = 0.028) and of both the GG and GA genotypes (85.8 vs. 79.8%, p = 0.025) of the G196A polymorphism in AD subjects than in controls and higher frequency of the T allele of the C270T polymorphism in AD subjects who were negative for apolipotrotein E4 (2.0 vs. 4.4%, p = 0.035) or positive for AD family history (2.8 vs. 7.1%, p = 0.046). These findings suggest that BDNF gene polymorphisms play some role in the development of AD.

本文言語English
ページ(範囲)703-711
ページ数9
ジャーナルJournal of Neural Transmission
112
5
DOI
出版ステータスPublished - 2005 5

ASJC Scopus subject areas

  • 神経学
  • 臨床神経学
  • 精神医学および精神衛生
  • 生物学的精神医学

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