Body fat mass is associated with ratio of steroid metabolites reflecting 17,20-lyase activity in prepubertal girls

Shin Hye Kim, Ju Yeon Moon, Hironobu Sasano, Man Ho Choi, Mi Jung Park

研究成果: Article査読

16 被引用数 (Scopus)

抄録

Context: Pediatric obesity has been related to hyperandrogenism and premature adrenarche in previous studies. However, little is known regarding the association between body fat mass and steroidogenic enzyme activities in children. Objective: To examine whether body fat mass is associated with serum steroid profiles in girls. Design, Participants, and Setting: We enrolled 242 girls (125 prepubertal, 117 pubertal; age, 7-13 years). Early morning blood samples were drawn at a university hospital to measure serum steroid profiles using gas chromatography-mass spectrometry, and steroidogenic enzyme activities were assessed from the ratios of steroid metabolites. Main Outcome Measures: We evaluated serum steroid profiles and estimated steroidogenic enzyme activities and their association with anthropometric indices and body composition. Results: Prepubertal obese girls demonstrated significantly higher progestin, androgens (dehydroepiandrosterone [DHEA], androstenedione [A-dione], T, androsterone), and ratio of steroid metabolites reflecting 17,20-lyase activity [(DHEA + A-dione)/17-hydroxypregnenolone] compared with prepubertal controls. Pubertal obese girls demonstrated significantly higher serum T and androsterone than pubertal controls; however, serum steroid metabolite ratios reflecting steroidogenic enzyme activities did not significantly differ among obese and non-obese girls. Partial correlation analysis revealed that body fat mass was positively correlated with pregnenolone, DHEA, A-dione, T, androsterone, and ratio of (DHEA + A-dione)/17-hydroxypregnenolone in prepubertal girls only. Prepubertal girls with increased body fat mass had significantly higher serum DHEA and ratio of (DHEA + A-dione)/17-hydroxypregnenolone than controls. Conclusions: Increased androgen production in prepubertal obese girls could be at least partly due to increased body fat mass and 17,20-lyase activity.

本文言語English
ページ(範囲)4653-4660
ページ数8
ジャーナルJournal of Clinical Endocrinology and Metabolism
101
12
DOI
出版ステータスPublished - 2016 12

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 生化学
  • 内分泌学
  • 臨床生化学
  • 生化学、医学

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