Blood glucose measurement with multiple quantum cascade lasers using hollow-optical fiber-based ATR spectroscopy

K. Yoshioka, S. Kino, Y. Matsuura

研究成果: Conference contribution

3 被引用数 (Scopus)

抄録

For non-invasive blood glucose measurement, a measurement system based on mid-infrared ATR spectroscopy equipped with a combination of a QCL as a light source and a hollow-optical fiber as a beam delivery medium is developed. Firstly the measurement sensitivity of the system is evaluated by using glucose solutions and the result shows a significant correlation between optical absorbance and solution concentration. It is also confirmed that the system has a sensitivity that is enough for blood glucose measurement. Then optical absorption of human lips in the mid-infrared wavelength region is measured using a QCL with a wavenumber of 1080 cm-1 where human tissue exhibits strong absorption of glucose and its metabolites. As a result, the measured absorption follows the change of blood glucose well with a time delay of around 10 minutes and correlation factor between the absorbance and the blood glucose level is 0.42.

本文言語English
ホスト出版物のタイトルOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII
編集者Israel Gannot, Israel Gannot
出版社SPIE
ISBN(電子版)9781510614611
DOI
出版ステータスPublished - 2018 1 1
イベントOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII 2018 - San Francisco, United States
継続期間: 2018 1 272018 1 28

出版物シリーズ

名前Progress in Biomedical Optics and Imaging - Proceedings of SPIE
10488
ISSN(印刷版)1605-7422

Other

OtherOptical Fibers and Sensors for Medical Diagnostics and Treatment Applications XVIII 2018
CountryUnited States
CitySan Francisco
Period18/1/2718/1/28

ASJC Scopus subject areas

  • Electronic, Optical and Magnetic Materials
  • Biomaterials
  • Atomic and Molecular Physics, and Optics
  • Radiology Nuclear Medicine and imaging

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