Bisphenol A diglycidyl ether (BADGE) suppresses tumor necrosis factor-α production as a PPARγ agonist in the murine macrophage-like cell line, RAW 264.7

Makoto Nakamuta, Munechika Enjoji, Koutaro Uchimura, Satoshi Ohta, Rie Sugimoto, Kazuhiro Kotoh, Masaki Kato, Takashi Irie, Tatsushi Muta, Hajime Nawata

研究成果: Article査読

29 被引用数 (Scopus)

抄録

Bisphenol A diglycidyl ether (BADGE) is a newly described peroxisome proliferator-activated receptor γ (PPARγ) antagonist in adipogenic cells. In contrast, in the macrophage-like cell line RAW 264.7, BADGE, like the PPARγ agonist pioglitazone hydrochloride, not only increased promoter activity of the PPARγ-luciferase reporter gene, but also suppressed lipopolysaccharide (LPS)-induced tumor necrosis factor-α (TNF-α) production. These results suggest that BADGE is a PPARγ agonist in RAW 264.7 cells. Furthermore, overexpression of the coactivator p300 restored BADGE- or pioglitazone hydrochloride-suppressed promoter activity of the nuclear factor-kappa B (NF-κB)-luciferase reporter gene, suggesting that PPARγ may interfere with NF-κB transcriptional activity via coactivator competition.

本文言語English
ページ(範囲)235-241
ページ数7
ジャーナルCell Biology International
26
3
DOI
出版ステータスPublished - 2002
外部発表はい

ASJC Scopus subject areas

  • 細胞生物学

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