Bis(methylmercuric) selenide as a reaction product from methylmercury and selenite in rabbit blood

Akira Naganuma, N. Imura

研究成果: Article査読

83 被引用数 (Scopus)

抄録

The compound formed by the reaction of methylmercury and selenite in rabbit blood was characterized. When methylmercuric chloride (10 nmol) and sodium selenite (10 nmol) were added to rabbit blood (1 ml), about 6.5 nmol of mercury and 3.2 nmol of selenium were extracted with benzene. Mercury and selenium thus transferred into benzene at the molar ratio of 2:1 were confirmed to form a single compound which was identified as bis(methylmercuric) selenide: (CH3Hg)2Se. The formation of (CH3Hg)2Se from methylmercury and selenite in blood, presumably by the participation of glutathione (GSH), might play a role in the protective effect of selenium against methylmercury toxicity.

本文言語English
ページ(範囲)163-173
ページ数11
ジャーナルResearch Communications in Chemical Pathology and Pharmacology
27
1
出版ステータスPublished - 1980 1月 1

ASJC Scopus subject areas

  • 病理学および法医学
  • 毒物学
  • 薬理学
  • 薬理学、毒性学および薬学(全般)

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