Biosensors for the Detection of OP Nerve Agents

Jun Ichi Anzai

研究成果: Chapter

3 被引用数 (Scopus)

抄録

This chapter reviews recent studies of biosensors for detecting organophosphorus (OP) nerve agents. Different detection modes using different enzymes and combinations of them are applicable to constructing OP biosensors using electrochemical principles. Among them, use of the organophosphorus hydrolase (OPH) enzyme is superior to other protocols because OPH-based biosensors directly detect OP compounds in a single step as compared to the inhibition-mode biosensors based on cholinesterase (ChE) and ChE-choline oxidase (ChOx) enzymes, which require two-step operation. One advantage of electrochemical biosensors in OP detection is that a portable device can easily be prepared for in-field analysis. Easy biosensor operation is another benefit when compared to chromatographic or spectroscopic measurements. Therefore, biosensors have a high potential for fast on-site screening of OP nerve agents.

本文言語English
ホスト出版物のタイトルHandbook of Toxicology of Chemical Warfare Agents
ホスト出版物のサブタイトルSecond Edition
出版社Elsevier Inc.
ページ925-934
ページ数10
ISBN(印刷版)9780128001592
DOI
出版ステータスPublished - 2015 1 21

ASJC Scopus subject areas

  • 医学(全般)

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