Biomimetic tissues on a chip for drug discovery

Amir M. Ghaemmaghami, Matthew J. Hancock, Helen Harrington, Hirokazu Kaji, Ali Khademhosseini

研究成果: Review article査読

245 被引用数 (Scopus)

抄録

Developing biologically relevant models of human tissues and organs is an important enabling step for disease modeling and drug discovery. Recent advances in tissue engineering, biomaterials and microfluidics have led to the development of microscale functional units of such models also referred to as 'organs on a chip'. In this review, we provide an overview of key enabling technologies and highlight the wealth of recent work regarding on-chip tissue models. In addition, we discuss the current challenges and future directions of organ-on-chip development.

本文言語English
ページ(範囲)173-181
ページ数9
ジャーナルDrug Discovery Today
17
3-4
DOI
出版ステータスPublished - 2012 2

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery

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