TY - JOUR
T1 - Biomimetic tissues on a chip for drug discovery
AU - Ghaemmaghami, Amir M.
AU - Hancock, Matthew J.
AU - Harrington, Helen
AU - Kaji, Hirokazu
AU - Khademhosseini, Ali
N1 - Funding Information:
AMG was supported by an International Scientific Interchange Scheme award ( BB/I02643X/1 ) and a project grant (BB/H011293/1) from the Biotechnology and Biological Sciences Research Council (BBSRC), UK. HK was supported by a JSPS Fellowship for Research Abroad and Grant-in-Aid for Young Scientists (A) (23681027) from the Ministry of Education, Science and Culture, Japan. AK would like to acknowledge funding by the National Institutes of Health ( HL092836 , DE019024 , EB012597 , AR057837 , DE021468 , HL099073 , EB008392 ), the Office of Naval Research, the National Science Foundation and the US Army Corps of Engineers.
PY - 2012/2
Y1 - 2012/2
N2 - Developing biologically relevant models of human tissues and organs is an important enabling step for disease modeling and drug discovery. Recent advances in tissue engineering, biomaterials and microfluidics have led to the development of microscale functional units of such models also referred to as 'organs on a chip'. In this review, we provide an overview of key enabling technologies and highlight the wealth of recent work regarding on-chip tissue models. In addition, we discuss the current challenges and future directions of organ-on-chip development.
AB - Developing biologically relevant models of human tissues and organs is an important enabling step for disease modeling and drug discovery. Recent advances in tissue engineering, biomaterials and microfluidics have led to the development of microscale functional units of such models also referred to as 'organs on a chip'. In this review, we provide an overview of key enabling technologies and highlight the wealth of recent work regarding on-chip tissue models. In addition, we discuss the current challenges and future directions of organ-on-chip development.
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U2 - 10.1016/j.drudis.2011.10.029
DO - 10.1016/j.drudis.2011.10.029
M3 - Review article
C2 - 22094245
AN - SCOPUS:84856441579
SN - 1359-6446
VL - 17
SP - 173
EP - 181
JO - Drug Discovery Today
JF - Drug Discovery Today
IS - 3-4
ER -
