TY - JOUR
T1 - Biomimetic tissues on a chip for drug discovery
AU - Ghaemmaghami, Amir M.
AU - Hancock, Matthew J.
AU - Harrington, Helen
AU - Kaji, Hirokazu
AU - Khademhosseini, Ali
PY - 2012/2
Y1 - 2012/2
N2 - Developing biologically relevant models of human tissues and organs is an important enabling step for disease modeling and drug discovery. Recent advances in tissue engineering, biomaterials and microfluidics have led to the development of microscale functional units of such models also referred to as 'organs on a chip'. In this review, we provide an overview of key enabling technologies and highlight the wealth of recent work regarding on-chip tissue models. In addition, we discuss the current challenges and future directions of organ-on-chip development.
AB - Developing biologically relevant models of human tissues and organs is an important enabling step for disease modeling and drug discovery. Recent advances in tissue engineering, biomaterials and microfluidics have led to the development of microscale functional units of such models also referred to as 'organs on a chip'. In this review, we provide an overview of key enabling technologies and highlight the wealth of recent work regarding on-chip tissue models. In addition, we discuss the current challenges and future directions of organ-on-chip development.
UR - http://www.scopus.com/inward/record.url?scp=84856441579&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84856441579&partnerID=8YFLogxK
U2 - 10.1016/j.drudis.2011.10.029
DO - 10.1016/j.drudis.2011.10.029
M3 - Review article
C2 - 22094245
AN - SCOPUS:84856441579
VL - 17
SP - 173
EP - 181
JO - Drug Discovery Today
JF - Drug Discovery Today
SN - 1359-6446
IS - 3-4
ER -