Biochemical markers of bone turnover. New aspect. Nitric oxide synthase and bone metabolism

Ken Sabanai, Masato Tsutsui, Akinori Sakai, Toshitaka Nakamura, Hiroaki Shimokawa, Nobuyuki Yanagihara

研究成果: Review article査読

5 被引用数 (Scopus)

抄録

It remains to be determined the role of the nitric oxide synthase (NOS) system in bone metabolism. We addressed this point in mice with complete disruption of the NOS system (triply n/i/eNOS(-/-) mice) that we have recently developed, and clarified that the triply NOS( - / - ) mice manifested increased bone mineral density and accelerated bone turnover in vivo. These results provide the first direct evidence that the entire NOS system plays an important role in the regulation of bone metabolism.

本文言語English
ページ(範囲)1133-1141
ページ数9
ジャーナルClinical calcium
19
8
出版ステータスPublished - 2009 8

ASJC Scopus subject areas

  • 医学(全般)

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