Biochemical consequences of biotin deficiency in osteogenic disorder shionogi rats.

Y. Furukawa, T. Numazawa, H. Fukazawa, M. Ikai, K. Ohinata, M. Maebashi, D. H. Kim, M. Ito, M. Komai, S. Kimura

研究成果: Article査読

3 被引用数 (Scopus)

抄録

The biological consequences of biotin deficiency in rats were investigated using osteogenic disorder Shionogi rats which have a hereditary defect in ascorbic acid synthesizing ability. Decrease of liver ascorbic acid content and fasting plasma glucose and an increase of plasma non-esterified fatty acid (NEFA) appeared in biotin deficient rats fed a diet containing 200 mg ascorbic acid per 100 g diet, compared with the pair fed control. On the other hand, in the case of rats fed a diet containing 500 mg ascorbic acid, although the clinical features of biotin deficiency developed, the ascorbic acid contents of liver and adrenal gland increased in comparison with those of AsA 200 mg groups, and the alterations of plasma levels of glucose and NEFA were improved partially in glucose and greatly in NEFA, respectively. This suggests that ascorbic acid may be consumed in the improvement of the metabolic impairments induced by biotin deficiency.

本文言語English
ページ(範囲)129-134
ページ数6
ジャーナルInternational Journal for Vitamin and Nutrition Research
63
2
出版ステータスPublished - 1993 1 1

ASJC Scopus subject areas

  • 医学(その他)
  • 内分泌学、糖尿病および代謝内科学
  • 栄養および糖尿病

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