Bio-inspired Incrustation Interfacial Polymerization of Dopamine and Cross-linking with Gelatin toward Robust, Biodegradable Three-Dimensional Hydrogels

研究成果: Article査読

抄録

In nature, laccase enzymatically catalyzes the reaction of phenolic compounds with oxygen to produce hardened surfaces known as cuticles on insects and plants. Inspired by this natural process, the present work investigated a robust, biodegradable hydrogel synthesized from dopamine and gelatin. This gel is obtained by the oxidation of dopamine dissolved in water, after which the resulting quinone compound automatically undergoes self-polymerization. The oxidized dopamine subsequently undergoes Schiff base and Michael addition reactions with gelatin, such that the exposed gelatin surface cross-links to generate a continuous hardened hydrogel film. Because gelatin transitions between sol and gel states with changes in temperature, two- and three-dimensional structures could be obtained from the gel state. This bio-inspired interfacial cross-linking reaction provides a simple means of forming complex morphologies and represents a promising technique for bio-applications.

本文言語English
ページ(範囲)6201-6207
ページ数7
ジャーナルLangmuir
37
20
DOI
出版ステータスPublished - 2021 5 25

ASJC Scopus subject areas

  • 材料科学(全般)
  • 凝縮系物理学
  • 表面および界面
  • 分光学
  • 電気化学

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