Beyond the C18 frontier: Androgen and glucocorticoid metabolism in breast cancer tissues: The role of non-typical steroid hormones in breast cancer development and progression

Keely May McNamara, Hironobu Sasano

研究成果: Review article査読

5 被引用数 (Scopus)

抄録

Breast cancer's hormonal dependence is well known and has been so for a long time. However in the last two decades great advances have been made in understanding the local metabolism of steroids within tissue. In the form of aromatase inhibition this is already one of the mainstays of breast cancer therapy. This review aims to summarise briefly what is known in terms of the metabolism of C18 steroids but perhaps more importantly to touch on the new developments regarding the importance of the metabolism of androgens and glucocorticoids in breast tissue. It is our hope that this review should provide the reader with a "birds eye view" of the current state of knowledge regarding localised steroid metabolism in the breast.

本文言語English
ページ(範囲)115-122
ページ数8
ジャーナルSteroids
103
DOI
出版ステータスPublished - 2015 11 1

ASJC Scopus subject areas

  • 生化学
  • 分子生物学
  • 内分泌学
  • 薬理学
  • 臨床生化学
  • 有機化学

フィンガープリント

「Beyond the C18 frontier: Androgen and glucocorticoid metabolism in breast cancer tissues: The role of non-typical steroid hormones in breast cancer development and progression」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル