Aza-Henry reaction of ketimines catalyzed by guanidine and phosphazene bases

Nirmal K. Pahadi, Hitoshi Ube, Masahiro Terada

研究成果: Article査読

40 被引用数 (Scopus)

抄録

A general catalytic addition of nitromethane to simple N-diphenylphosphinoyl ketimines is achieved using either 10 mol % 1,1,3,3-tetramethylguanidine (TMG) or 10 mol % phosphazene (t-Bu-P1) as organic base catalysts in good to high yields. On the other hand, N-sulfinylketimines also furnished the aza-Henry product in good yield with moderate diastereoselectivity (3:1). Thus, the methodology developed here is a good template for developing the first organocatalytic approach towards the aza-Henry reaction of ketimines.

本文言語English
ページ(範囲)8700-8703
ページ数4
ジャーナルTetrahedron Letters
48
49
DOI
出版ステータスPublished - 2007 12月 3

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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