Axisymmetric polydimethysiloxane microchannels for in vitro hemodynamic studies

Rui Lima, Mónica S.N. Oliveira, Takuji Ishikawa, Hirokazu Kaji, Shuji Tanaka, Matsuhiko Nishizawa, Takami Yamaguchi

研究成果: Article査読

37 被引用数 (Scopus)

抄録

The current microdevices used for biomedical research are often manufactured using microelectromechanical systems (MEMS) technology. Although it is possible to fabricate precise and reproducible rectangular microchannels using soft lithography techniques, this kind of geometry may not reflect the actual physiology of the microcirculation. Here, we present a simple method to fabricate circular polydimethysiloxane (PDMS) microchannels aiming to mimic an in vivo microvascular environment and suitable for state-of-the-art microscale flow visualization techniques, such as confocal νPIV/PTV. By using a confocal νPTV system individual red blood cells (RBCs) were successfully tracked trough a 75 νm circular PDMS microchannel. The results show that RBC lateral dispersion increases with the volume fraction of RBCs in the solution, i.e. with the hematocrit.

本文言語English
論文番号035005
ジャーナルBiofabrication
1
3
DOI
出版ステータスPublished - 2009

ASJC Scopus subject areas

  • バイオテクノロジー
  • バイオエンジニアリング
  • 生化学
  • 生体材料
  • 生体医工学

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