Auxin-Dependent cell cycle reactivation through transcriptional regulation of arabidopsis E2Fa by lateral organ boundary proteins

Barbara Berckmans, Valya Vassileva, Stephan P.C. Schmid, Sara Maes, Boris Parizot, Satoshi Naramoto, Zoltan Magyar, Claire Lessa Alvim Kamei, Csaba Koncz, Laszlo Bögre, Geert Persiau, Geert de Jaeger, Jiří Friml, Rüdiger Simon, Tom Beeckman, Lieven de Veyldera

研究成果: Article査読

144 被引用数 (Scopus)

抄録

Multicellular organisms depend on cell production, cell fate specification, and correct patterning to shape their adult body. In plants, auxin plays a prominent role in the timely coordination of these different cellular processes. A well-studied example is lateral root initiation, in which auxin triggers founder cell specification and cell cycle activation of xylem pole- positioned pericycle cells. Here, we report that the E2Fa transcription factor of Arabidopsis thaliana is an essential component that regulates the asymmetric cell division marking lateral root initiation. Moreover, we demonstrate that E2Fa expression is regulated by the LATERAL ORGAN BOUNDARY DOMAIN18/LATERAL ORGAN BOUNDARY DOMAIN33 (LBD18/ LBD33) dimer that is, in turn, regulated by the auxin signaling pathway. LBD18/LBD33 mediates lateral root organogenesis through E2Fa transcriptional activation, whereas E2Fa expression under control of the LBD18 promoter eliminates the need for LBD18. Besides lateral root initiation, vascular patterning is disrupted in E2Fa knockout plants, similarly as it is affected in auxin signaling and lbd mutants, indicating that the transcriptional induction of E2Fa through LBDs represents a general mechanism for auxin-dependent cell cycle activation. Our data illustrate how a conserved mechanism driving cell cycle entry has been adapted evolutionarily to connect auxin signaling with control of processes determining plant architecture.

本文言語English
ページ(範囲)3671-3683
ページ数13
ジャーナルPlant Cell
23
10
DOI
出版ステータスPublished - 2011 12月
外部発表はい

ASJC Scopus subject areas

  • 植物科学
  • 細胞生物学

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