Autotaxin–lysophosphatidic acid pathway in intraocular pressure regulation and glaucoma subtypes

Megumi Honjo, Nozomi Igarashi, Makoto Kurano, Yutaka Yatomi, Koji Igarashi, Kuniyuki Kano, Junken Aoki, Robert N. Weinreb, Makoto Aihara

研究成果: Article

11 引用 (Scopus)

抜粋

Purpose: To compare the levels of autotaxin (ATX), lysophosphatidic acid (LPA), and lysophosphatidylcholine (LPC) in the aqueous humor (AH) of healthy control subjects with those of patients with different subtypes of glaucoma, and also to investigate the relationship of the ATX–LPA pathway with IOP and subtype of glaucoma. Methods: This study included 164 eyes of 164 consecutive cases of cataract and glaucoma surgery (37 healthy, 31 normal tension glaucoma, 49 primary open angle glaucoma, 28 secondary open angle glaucoma, and 19 exfoliation glaucoma). Aqueous levels of LPA, LPC, and ATX were quantified using liquid chromatography-tandem mass spectrometry and a two-site immunoenzymetric assay. The association between aqueous levels of ATX/LPA/LPC and IOP elevation in different glaucoma subtypes was investigated. The diagnostic values of indices of the ATX–LPA pathway were compared using receiver operating characteristic curve analysis. Results: Notable increases in ATX/LPA/LPC levels in glaucoma patients were observed. The ATX–LPA pathway was significantly related to IOP elevation and the subtype of glaucoma, especially in SOAG and XFG patients, and the area under the curve was significant for discriminating glaucoma eyes from healthy eyes. Conclusions: Bioactive ATX/LPA/LPC concentrations were present in aqueous humor, and higher ATX and LPA concentrations were significantly correlated with IOP in all study subjects. Furthermore, the ATX–LPA pathway was significantly related to glaucoma subtype. These results reveal the potentially important role of the ATX–LPA pathway for IOP regulation in healthy subjects and glaucoma patients.

元の言語English
ページ(範囲)693-701
ページ数9
ジャーナルInvestigative Ophthalmology and Visual Science
59
発行部数2
DOI
出版物ステータスPublished - 2018 2

ASJC Scopus subject areas

  • Ophthalmology
  • Sensory Systems
  • Cellular and Molecular Neuroscience

フィンガープリント Autotaxin–lysophosphatidic acid pathway in intraocular pressure regulation and glaucoma subtypes' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

  • これを引用

    Honjo, M., Igarashi, N., Kurano, M., Yatomi, Y., Igarashi, K., Kano, K., Aoki, J., Weinreb, R. N., & Aihara, M. (2018). Autotaxin–lysophosphatidic acid pathway in intraocular pressure regulation and glaucoma subtypes. Investigative Ophthalmology and Visual Science, 59(2), 693-701. https://doi.org/10.1167/iovs.17-23218