Autophagosomes can support Yersinia pseudotuberculosis replication in macrophages

Kevin Moreau, Sandra Lacas-Gervais, Naonobu Fujita, Florent Sebbane, Tamotsu Yoshimori, Michel Simonet, Frank Lafont

    研究成果: Article

    49 引用 (Scopus)

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    Summary: Yersinia pseudotuberculosis is able to replicate inside macrophages. However, the intracellular trafficking of the pathogen after its entry into the macrophage remains poorly understood. Using in vitro infected bone marrow-derived macrophages, we show that Y. pseudotuberculosis activates the autophagy pathway. Host cell autophagosomes subverted by bacteria do not become acidified and sustain bacteria replication. Moreover, we report that autophagy inhibition correlated with bacterial trafficking inside an acidic compartment. This study indicates that Y. pseudotuberculosis hijacks the autophagy pathway for its replication and also opens up new opportunities for deciphering the molecular basis of the host cell signalling response to intracellular Yersinia infection.

    元の言語English
    ページ(範囲)1108-1123
    ページ数16
    ジャーナルCellular Microbiology
    12
    発行部数8
    DOI
    出版物ステータスPublished - 2010 8

    ASJC Scopus subject areas

    • Microbiology
    • Immunology
    • Virology

    フィンガープリント Autophagosomes can support Yersinia pseudotuberculosis replication in macrophages' の研究トピックを掘り下げます。これらはともに一意のフィンガープリントを構成します。

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    Moreau, K., Lacas-Gervais, S., Fujita, N., Sebbane, F., Yoshimori, T., Simonet, M., & Lafont, F. (2010). Autophagosomes can support Yersinia pseudotuberculosis replication in macrophages. Cellular Microbiology, 12(8), 1108-1123. https://doi.org/10.1111/j.1462-5822.2010.01456.x