Autoantibodies against β-crystallins induce lens epithelial cell damage and cataract formation in mice

D. P. Singh, S. C. Guru, T. Kikuchi, Toshiaki Abe, T. Shinohara

研究成果: Article査読

20 被引用数 (Scopus)

抄録

One-year-old B6C3/f mice, injected with β-crystallins emulsified with CFA, developed lens epithelial cell damage. Both serum transfer and mAb transfer studies clearly established that the autoimmune insult is induced by humoral immunity. Older mice were more susceptible to autoimmune insult than younger animals. Lens epithelial cell damage invariably proceeded to cortical and posterior subcapsular cataract formation. This mouse model of experimental autoimmune cataract formation will facilitate the exploration of the relation between immune phenomena and human age-related cataract.

本文言語English
ページ(範囲)993-999
ページ数7
ジャーナルJournal of Immunology
155
2
出版ステータスPublished - 1995 1 1
外部発表はい

ASJC Scopus subject areas

  • Immunology

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