TY - JOUR
T1 - Auto iris pigment epithelial cell transplantation in patients with age-related macular degeneration
T2 - Short-term results
AU - Abe, Toshiaki
AU - Yoshida, Madoka
AU - Tomita, Hiroshi
AU - Kano, Tetsuya
AU - Sato, Masami
AU - Wada, Yuko
AU - Fuse, Nobuo
AU - Yamada, Tasuku
AU - Tamai, Makoto
N1 - Copyright:
Copyright 2017 Elsevier B.V., All rights reserved.
PY - 2000/5
Y1 - 2000/5
N2 - Autologous iris pigment epithelial cell transplantation was performed on patients with exudative age-related macular degeneration (AMD). Autologous IPE cell culture was performed using autologous serum after iridectomy in 7 patients with AMD. The cell suspensions (2∼20 × 104 cells) were transplanted into the submacular lesion of individuals after removal of neovascular membranes. Subsequent ophthalmological examinations, including best corrected visual acuity and fluorescein or indocyanine green angiography, were performed. In addition, 15 patients with AMD, who underwent removal of neovascular membrane without transplantation, were evaluated as non randomized controls. Varying degrees of atrophy or defects of choriocapillaris and retinal pigment epithelium were observed in all of the patients. No cystoid macular edema or fluorescein leakage was observed after treatment, but window defects were present. No patient had decreased visual acuity. One treated patient developed mild subretinal fibrosis and an other patient developed mild preretinal fibrosis, however no difference was significant when compared with the control. In coclusion, the treatment resulted in no significant improvement in macular function, as compared with the control; however, no rejection or deterioration in visual acuity occurred up to the 13 month follow up.
AB - Autologous iris pigment epithelial cell transplantation was performed on patients with exudative age-related macular degeneration (AMD). Autologous IPE cell culture was performed using autologous serum after iridectomy in 7 patients with AMD. The cell suspensions (2∼20 × 104 cells) were transplanted into the submacular lesion of individuals after removal of neovascular membranes. Subsequent ophthalmological examinations, including best corrected visual acuity and fluorescein or indocyanine green angiography, were performed. In addition, 15 patients with AMD, who underwent removal of neovascular membrane without transplantation, were evaluated as non randomized controls. Varying degrees of atrophy or defects of choriocapillaris and retinal pigment epithelium were observed in all of the patients. No cystoid macular edema or fluorescein leakage was observed after treatment, but window defects were present. No patient had decreased visual acuity. One treated patient developed mild subretinal fibrosis and an other patient developed mild preretinal fibrosis, however no difference was significant when compared with the control. In coclusion, the treatment resulted in no significant improvement in macular function, as compared with the control; however, no rejection or deterioration in visual acuity occurred up to the 13 month follow up.
KW - Age-related macular degeneration
KW - Auto iris pigment epithelium
KW - Rejection
KW - Transplantation
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U2 - 10.1620/tjem.191.7
DO - 10.1620/tjem.191.7
M3 - Article
C2 - 10896035
AN - SCOPUS:0034186383
VL - 191
SP - 7
EP - 20
JO - Tohoku Journal of Experimental Medicine
JF - Tohoku Journal of Experimental Medicine
SN - 0040-8727
IS - 1
ER -