Autism spectrum disorder (ASD): Disturbance of the melatonin system and its implications

Zhou yue Wu, Shu dai Huang, Jin jun Zou, Qin xin Wang, Muhammad Naveed, Hai nan Bao, Wei Wang, Kohji Fukunaga, Feng Han

研究成果: Review article査読

7 被引用数 (Scopus)

抄録

The molecular mechanisms underlying autism spectrum disorder (ASD) remain elusive, which limits the management options available in the clinic. Accumulating evidence indicates that the pineal gland/melatonin system is associated with the progression of ASD. Here, we review recent advances in our understanding of various mechanisms involving pathological process of ASD, including the abnormal breakdown of melatonin synthesis, the disturbance of intracellular MTNR1A signaling, the effects exerted by melatonin on hippocampal protein serine/threonine kinases, and immune dysregulation/inflammation during ASD. We believe that an in-depth understanding of the interplay between the action of the melatonin system and the onset of autism could promote the development of novel therapeutic strategies against ASD. We anticipate that targeting the neurotransmitters upstream pathway and downstream of melatonin in brain will lead to potential therapeutic treatment for ASD.

本文言語English
論文番号110496
ジャーナルBiomedicine and Pharmacotherapy
130
DOI
出版ステータスPublished - 2020 10

ASJC Scopus subject areas

  • 薬理学

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