Augmentation of interferon production after cell-differentiation of U937 cells by TPA

Tomokazu Indoh, Sachiko Shirakawa, Tohru Kubota, Teruo Yashiki, Emiko Isogai, Nobuhiro Fujii

研究成果: Article査読

5 被引用数 (Scopus)

抄録

Persistent infections with mumps virus were established in several human lymphoid cells of T-cell origin (Molt-4, TALL-1, and CCRF-CEM) and human monocyte cells (U937 and THP-1). 2',5'-Oligoadenylate synthetase (2-5AS) activity was demonstrated to be only slightly induced by interferon (IFN) or TPA (12-O-tetradecanoyl-phorbol-13-acetate) treatment in these cells. Treatment of the persistently infected cells with IFN or TPA did not stimulate an increase in the amount of synthetase mRNA. Induction of cell differentiation and augmentation of IFN production by TPA were demonstrated in U937 cells persistently infected with mumps virus (U937-MP). Similar results for IFN production were obtained from differentiated U937 cells. It is suggested that cell differentiation of U937 cells might be associated with the development of IFN inducibility.

本文言語English
ページ(範囲)675-679
ページ数5
ジャーナルMICROBIOLOGY and IMMUNOLOGY
40
9
DOI
出版ステータスPublished - 1996

ASJC Scopus subject areas

  • 微生物学
  • 免疫学
  • ウイルス学

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