ATTENUATED RENAL RESPONSE TO ATRIAL NATRIURETIC PEPTIDE INFUSION IN RATS WITH HEART FAILURE

Masahiro Kohzuki, G. Peter Hodsman, Richard W. Harrison, Colin I. Johnston

研究成果: Article査読

2 被引用数 (Scopus)

抄録

1. The natriuretic and diuretic effects of three atrial natriuretic peptide (ANP) infusion rates were examined in rats 4 weeks after myocardial infarction induced by left coronary artery ligation. 2. The natriuretic and diuretic effects of ANP were observed in controls and rats with infarction, but the effects were significantly attenuated in the latter. 3. Rats with chronic left heart failure were less sensitive to the renal effects of ANP compared with controls. 4. Impaired sodium and water excretion in chronic heart failure may be due partly to an attenuated renal response to ANP.

本文言語English
ページ(範囲)323-326
ページ数4
ジャーナルClinical and Experimental Pharmacology and Physiology
15
4
DOI
出版ステータスPublished - 1988 1月 1
外部発表はい

ASJC Scopus subject areas

  • 生理学
  • 薬理学
  • 生理学(医学)

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