Atrial natriuretic peptide infusion in chronic heart failure in the rat

M. Kohzuki, G. P. Hodsman, R. W. Harrison, P. S. Western, C. I. Johnston

研究成果: Article査読

10 被引用数 (Scopus)


The natriuretic, diuretic, and hypotensive responses to infused atrial natriuretic peptide (ANP) were measured in rats 4 weeks after myocardial infarction induced by coronary artery ligation. Rat [1-28]-ANP was infused intravenously in doses of 0.1, 0.3, and 1.0 μg/kg/min for 30 min each under pentobarbital anesthesia. There was a marked natriuresis, diuresis, and fall in blood pressure in rats with infarction but each response was significantly attenuated when compared with sham-operated controls (ANOVA: p < 0.01, p < 0.05, and p < 0.01, respectively). Urinary cyclic guanosine monophosphate (cGMP) excretion in rats with infarction was higher than that of controls but rose to the same absolute level in both groups in response to ANP infusion (0.3 μg/kg/min). Reduced ANP responsiveness may result from impaired postreceptor mechanisms or from physiological antagonism by angiotensin II. Reduced ANP responsiveness may partly explain impaired salt handling in heart failure.

ジャーナルJournal of Cardiovascular Pharmacology
出版ステータスPublished - 1989 1 1

ASJC Scopus subject areas

  • 薬理学
  • 循環器および心血管医学


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