Asymmetric transfer hydrogenation in aqueous media catalyzed by resin-supported peptide having a polyleucine tether

Kengo Akagawa, Hajime Akabane, Seiji Sakamoto, Kazuaki Kudo

研究成果: Article査読

37 被引用数 (Scopus)

抄録

A resin-supported N-terminal prolyl peptide having a β-turn motif and a polyleucine tether has been developed for the organocatalytic asymmetric transfer hydrogenation under aqueous conditions. Polyleucine accelerated the reaction in a highly enantioselective manner by providing a hydrophobic microenvironment around the prolyl residue. The investigation of catalyst structures indicates that the l-form of polyleucine is essential for both reaction efficiency and enantioselectivity.

本文言語English
ページ(範囲)461-466
ページ数6
ジャーナルTetrahedron Asymmetry
20
4
DOI
出版ステータスPublished - 2009 3月 11

ASJC Scopus subject areas

  • 触媒
  • 物理化学および理論化学
  • 有機化学
  • 無機化学

フィンガープリント

「Asymmetric transfer hydrogenation in aqueous media catalyzed by resin-supported peptide having a polyleucine tether」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

引用スタイル