Asymmetric synthesis of methylenecyclobutanes and their transformation to medium-sized carbocyclic compounds

Koichi Narasaka, Kazuhiro Hayashi, Yujiro Hayashi

研究成果: Article査読

23 被引用数 (Scopus)

抄録

The catalytic asymmetric [2+2] cycloaddition proceeds between 3-(2-alkenoyl)-1, 3-oxazolidin-2-ones and 1, 2-propadienyl sulfides having various substituents at 1-position, affording methylenecyclobutane derivatives with high optical purity. Seven and eight membered carbocycles with chiral side chains are prepared by the ring cleavage reaction and successive cationic cyclization of the chiral methylenecyclobutane derivatives having ω-alkenyl substituents.

本文言語English
ページ(範囲)4529-4542
ページ数14
ジャーナルTetrahedron
50
15
DOI
出版ステータスPublished - 1994 4月 11
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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