Asymmetric Synthesis of Functionalized 9-Methyldecalins Using a Diphenylprolinol-Silyl-Ether-Mediated Domino Michael/Aldol Reaction

Yujiro Hayashi, Hugo A. Salazar, Seitaro Koshino

研究成果: Article査読

抄録

Substituted 9-methyldecalin derivatives containing an all carbon quaternary chiral center were synthesized with excellent enantioselectivity via an organocatalyst-mediated domino reaction. The first reaction is a diphenylprolinol silyl ether-mediated Michael reaction, and the second reaction is an intramolecular aldol reaction. The enantiomerically pure catalyst is involved in both reactions.

本文言語English
ページ(範囲)6654-6658
ページ数5
ジャーナルOrganic letters
23
17
DOI
出版ステータスPublished - 2021 9 3

ASJC Scopus subject areas

  • 生化学
  • 物理化学および理論化学
  • 有機化学

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