Asymmetric Hydroacylation Involving Alkene Isomerization for the Construction of C3-Chirogenic Center

Chong Liu, Jing Yuan, Zhenfeng Zhang, Ilya D. Gridnev, Wanbin Zhang

研究成果: Article査読

3 被引用数 (Scopus)

抄録

A new transformation pattern for enantioselective intramolecular hydroacylation has been developed involving an alkene isomerization strategy. Proceeding through a five-membered rhodacycle intermediate, 3-enals were converted to C3- or C3,C5-chirogenic cyclopentanones with satisfactory yields, diastereoselectivities, and enantioselectivities. A catalytic cycle has been theoretically calculated and the origin of the stereoselection is rationally explained.

本文言語English
ページ(範囲)8997-9002
ページ数6
ジャーナルAngewandte Chemie - International Edition
60
16
DOI
出版ステータスPublished - 2021 4 12

ASJC Scopus subject areas

  • 触媒
  • 化学 (全般)

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