Asymmetric catalysis of ene-type reaction with fluoral by chiral titanium complex: A semi-empirical and ab-initio analysis of ene reactivity

Koichi Mikami, Tomoko Yajima, Masahiro Terada, Tadafumi Uchimaru

研究成果: Article査読

50 被引用数 (Scopus)

抄録

The chiral titanium complex-catalyzed ene-type reaction with fluoral is shown to serve as an efficient route for the asymmetric synthesis of CF3-substituted compounds of biological and synthetic importance in extremely high enantiomeric excesses (>95% ee). The ene reactivity of trihaloacetaldehyde including fluoral is estimated in terms of the balance of LUMO energy level vs. electron density on the carbonyl carbon.

本文言語English
ページ(範囲)7591-7594
ページ数4
ジャーナルTetrahedron Letters
34
47
DOI
出版ステータスPublished - 1993 11 19
外部発表はい

ASJC Scopus subject areas

  • 生化学
  • 創薬
  • 有機化学

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