Association of serum apolipoprotein B48 level with the presence of carotid plaque in type 2 diabetes mellitus

Kyoko Tanimura, Yasushi Nakajima, Mototugu Nagao, Akira Ishizaki, Toshiko Kano, Taro Harada, Fumitaka Okajima, Mariko Sudo, Hideki Tamura, Shinya Ishii, Hitoshi Sugihara, Shizuya Yamashita, Akira Asai, Shinichi Oikawa

研究成果: Article査読

24 被引用数 (Scopus)

抄録

Aims: The atherogenicity of chylomicron remnants has been discussed. We examined whether serum apoB48 level is associated with the presence of carotid plaque in type 2 diabetic patients. Method: Forty type 2 diabetic patients (21 males and 19 females, 52.8 ± 11.8 years old; mean ± S.D.) were divided into two groups by the presence or absence of carotid plaque. The diurnal change of serum apoB48 level was measured by enzyme-linked immunosorbent assay. Results: Fasting serum apoB48 level was higher in the subjects with carotid plaque than those without (6.5 ± 3.8 vs. 4.1 ± 1.9 μg/ml, p = 0.01). Age- and gender-adjusted analysis showed that the presence of carotid plaque was associated with fasting apoB48 (OR 1.43; 95% CI, 1.07-2.09, p = 0.04) and triglyceride (OR 1.14; 95% CI, 1.02-1.32, p = 0.04) levels. In normal LDL-cholesterol (<140 mg/dl) subjects, the presence of carotid plaque was associated with fasting apoB48 level (OR 2.16; 95% CI, 1.22-5.32, p = 0.04), but not associated with fasting triglyceride level (OR 1.11; 95% CI, 0.99-1.30, p = 0.13). Conclusions: Serum apoB48 level was strongly associated with the presence of carotid plaque in type 2 diabetic patients.

本文言語English
ページ(範囲)338-344
ページ数7
ジャーナルDiabetes Research and Clinical Practice
81
3
DOI
出版ステータスPublished - 2008 9
外部発表はい

ASJC Scopus subject areas

  • Internal Medicine
  • Endocrinology, Diabetes and Metabolism
  • Endocrinology

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