Association of body mass index and risk of death from pancreas cancer in Asians: Findings from the Asia Cohort Consortium

Yingsong Lin, Rong Fu, Eric Grant, Yu Chen, Jung Eun Lee, Prakash C. Gupta, Kunnambath Ramadas, Manami Inoue, Shoichiro Tsugane, Yu Tang Gao, Akiko Tamakoshi, Xiao Ou Shu, Kotaro Ozasa, Ichiro Tsuji, Masako Kakizaki, Hideo Tanaka, Chien Jen Chen, Keun Young Yoo, Yoon Ok Ahn, Habibul AhsanMangesh S. Pednekar, Catherine Sauvaget, Shizuka Sasazuki, Gong Yang, Yong Bing Xiang, Waka Ohishi, Takashi Watanabe, Yoshikazu Nishino, Keitaro Matsuo, San Lin You, Sue K. Park, Dong Hyun Kim, Faruque Parvez, Betsy Rolland, Dale McLerran, Rashmi Sinha, Paolo Boffetta, Wei Zheng, Mark Thornquist, Ziding Feng, Daehee Kang, John D. Potter

研究成果: Article査読

20 被引用数 (Scopus)

抄録

We aimed to examine the association between BMI and the risk of death from pancreas cancer in a pooled analysis of data from the Asia Cohort Consortium. The data for this pooled analysis included 883 529 men and women from 16 cohort studies in Asian countries. Cox proportional-hazards models were used to estimate the hazard ratios and 95% confidence intervals for pancreas cancer mortality in relation to BMI. Seven predefined BMI categories (<18.5, 18.5-19.9, 20.0-22.4, 22.5-24.9, 25.0-27.4, 27.5-29.9, ≥30) were used in the analysis, with BMI of 22.5-24.9 serving as the reference group. The multivariable analyses were adjusted for known risk factors, including age, smoking, and a history of diabetes. We found no statistically significant overall association between each BMI category and the risk of death from pancreas cancer in all Asians, and obesity was unrelated to the risk of mortality in both East Asians and South Asians. Age, smoking, and a history of diabetes did not modify the association between BMI and the risk of death from pancreas cancer. In planned subgroup analyses among East Asians, an increased risk of death from pancreas cancer among those with a BMI less than 18.5 was observed for individuals with a history of diabetes; hazard ratio=2.01 (95% confidence interval: 1.01-4.00) (P for interaction=0.07). The data do not support an association between BMI and the risk of death from pancreas cancer in these Asian populations.

本文言語English
ページ(範囲)244-250
ページ数7
ジャーナルEuropean Journal of Cancer Prevention
22
3
DOI
出版ステータスPublished - 2013 5

ASJC Scopus subject areas

  • 疫学
  • 腫瘍学
  • 公衆衛生学、環境および労働衛生
  • 癌研究

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