Association of a determinant on mouse chromosome 18 with experimental severe Plasmodium berghei malaria

Eiji Nagayasu, Koichi Nagakura, Mayumi Akaki, Gen Tamiya, Satoshi Makino, Yamaji Nakano, Minoru Kimura, Masamichi Aikawa

研究成果: Article査読

26 被引用数 (Scopus)

抄録

Experimental severe malaria (ESM; also known as experimental cerebral malaria) is an acute lethal syndrome caused by infection with Plasmodium berghei ANKA and associated with coma and other neurological manifestations in mice. Various inbred strains of mice exhibit differences in susceptibility to the development of ESM. For example, C57BL/6 mice are highly susceptible and DBA/2 mice are relatively resistant. We report here the results of a genomewide scan for host genomic regions that control resistance to ESM in DBA/2 mice using an F2 intercross population of susceptible and resistant strains. A region of mid-chromosome 18 was found to be a major determinant of resistance to ESM.

本文言語English
ページ(範囲)512-516
ページ数5
ジャーナルInfection and immunity
70
2
DOI
出版ステータスPublished - 2002
外部発表はい

ASJC Scopus subject areas

  • 寄生虫科
  • 微生物学
  • 免疫学
  • 感染症

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