TY - JOUR
T1 - Association between the combined fat mass and fat-free mass index and hypertension
T2 - The Tohoku Medical Megabank Community-based Cohort Study
AU - Takase, Masato
AU - Nakamura, Tomohiro
AU - Tsuchiya, Naho
AU - Kogure, Mana
AU - Itabashi, Fumi
AU - Narita, Akira
AU - Hirata, Takumi
AU - Nakaya, Naoki
AU - Hamanaka, Yohei
AU - Sugawara, Junichi
AU - Suzuki, Kichiya
AU - Fuse, Nobuo
AU - Uruno, Akira
AU - Kodama, Eiichi N.
AU - Kuriyama, Shinichi
AU - Tsuji, Ichiro
AU - Kure, Shigeo
AU - Hozawa, Atsushi
N1 - Funding Information:
This work was supported by the Japanese Society for the Promotion of Science (JSPS) through Grants-in-Aid for Scientific Research (C) [grant number 19K10637] and the Tohoku Medical Megabank Project from the Ministry of Education, Culture, Sports, Science, and Technology (MEXT) and the Japan Agency for Medical Research and Development (AMED) [grant number JP20km0105001]. The authors would like to thank the members of the Tohoku Medical Megabank Organization, including the Genome Medical Research Coordinators and the office and administrative personnel for their assistance. The complete list of members is available at: https://www.megabank.tohoku.ac.jp/english/a200601
Publisher Copyright:
© 2021 The Author(s). Published with license by Taylor & Francis Group, LLC.
PY - 2021
Y1 - 2021
N2 - Background: A higher body fat percentage is associated with hypertension, even in non-obese individuals. The difference in body composition may be related to hypertension. The fat mass index (FMI) and fat-free mass index (FFMI) are proposed indicators of body composition. This study aimed to examine the relationship of a combination of FMI and FFMI with hypertension. Methods: We conducted a cross-sectional study of 5,058 men and 11,842 women aged ≥ 20 years in the Miyagi Prefecture, northeastern Japan. The FMI and FFMI were calculated as the fat mass and fat-free mass divided by the height squared, respectively. The indices were classified into quartiles and combined into 16 groups. Hypertension was defined as casual blood pressure ≥ 140/90 mmHg and/or self-reported treatment for hypertension. Multivariable logistic regression models, adjusted for potential confounders, were used to assess the relationship of a combination of FMI and FFMI with hypertension. Results: Higher FMI was associated with hypertension in most of the FFMI subgroups. Similarly, a higher FFMI was associated with hypertension in most of FMI subgroups. For men, the association between FFMI and hypertension in the lowest FMI group was not significant. Conclusions: Reducing the FMI and FFMI may be important in preventing hypertension. For men, the relationship between the FFMI and hypertension in the lowest FMI group might be weak.
AB - Background: A higher body fat percentage is associated with hypertension, even in non-obese individuals. The difference in body composition may be related to hypertension. The fat mass index (FMI) and fat-free mass index (FFMI) are proposed indicators of body composition. This study aimed to examine the relationship of a combination of FMI and FFMI with hypertension. Methods: We conducted a cross-sectional study of 5,058 men and 11,842 women aged ≥ 20 years in the Miyagi Prefecture, northeastern Japan. The FMI and FFMI were calculated as the fat mass and fat-free mass divided by the height squared, respectively. The indices were classified into quartiles and combined into 16 groups. Hypertension was defined as casual blood pressure ≥ 140/90 mmHg and/or self-reported treatment for hypertension. Multivariable logistic regression models, adjusted for potential confounders, were used to assess the relationship of a combination of FMI and FFMI with hypertension. Results: Higher FMI was associated with hypertension in most of the FFMI subgroups. Similarly, a higher FFMI was associated with hypertension in most of FMI subgroups. For men, the association between FFMI and hypertension in the lowest FMI group was not significant. Conclusions: Reducing the FMI and FFMI may be important in preventing hypertension. For men, the relationship between the FFMI and hypertension in the lowest FMI group might be weak.
KW - Body composition
KW - epidemiology
KW - fat mass index
KW - fat-free mass index
KW - hypertension
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U2 - 10.1080/10641963.2021.1925681
DO - 10.1080/10641963.2021.1925681
M3 - Article
C2 - 34229544
AN - SCOPUS:85109937241
VL - 43
SP - 610
EP - 621
JO - Clinical and Experimental Hypertension
JF - Clinical and Experimental Hypertension
SN - 1064-1963
IS - 7
ER -