Association between recurrent metastasis from stage II and III primary colorectal tumors and moderate microsatellite instability

Melissa Garcia, Chan Choi, Hyeong Rok Kim, Yahya Daoud, Yuji Toiyama, Masanobu Takahashi, Ajay Goel, C. Richard Boland, Minoru Koi

研究成果: Article査読

36 被引用数 (Scopus)

抄録

Colorectal cancer cells frequently have low levels of microsatellite instability (MSI-L) and elevated microsatellite alterations at selected tetranucleotide repeats (EMAST), but little is known about the clinicopathologic significance of these features. We observed that patients with stage II or III colorectal cancer with MSI-L and/or EMAST had shorter times of recurrence-free survival than patients with high levels of MSI (P =.0084) or with highly stable microsatellites P =.0415), based on Kaplan-Meier analysis. MSI-L and/or EMAST were independent predictors of recurrent distant metastasis from primary stage II or III colorectal tumors (Cox proportional hazard analysis: hazard ratio, 1.83; 95% confidence interval, 1.06-3.15; P =.0301).

本文言語English
ページ(範囲)48-50.e1
ジャーナルGastroenterology
143
1
DOI
出版ステータスPublished - 2012 7
外部発表はい

ASJC Scopus subject areas

  • Hepatology
  • Gastroenterology

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