Assessment of cancer recurrence in residual tumors after fractionated radiotherapy: A comparison of fluorodeoxyglucose, L-methionine and thymidine

Michael J. Reinhardt, Kazuo Kubota, Susumu Yamada, Ren Iwata, Hiroshi Yaegashi

    研究成果: Article査読

    96 被引用数 (Scopus)

    抄録

    This study evaluates the midterm follow-up of tumor and normal tissue uptake of deoxyglucose, thymidine and methionine alter fractionated radiotherapy to assess cancer recurrence in residual tumors. Methods: AH109A tumor-burdened rats were treated with one to eight doses of 5Gy 60Co radiation. Tissue distribution study with 18F-FDG, 3H-thymidine and 14C- methionine, double-tracer autoradiography with 18F-FDG and 14C- methionine, and single-tracer autoradiography with 14C-labeled deoxyglucose, thymidine and methionine were performed 6 days after the end of therapy. Results: Dose response study shows a significant decrease of tumor uptake of all tracers after two and more doses, even in the ease of later recurrence. Whereas 3H-Thd and 14C-Met tumor uptake was similar to that of normal muscle, 18F-FDG tumor uptake remains higher than that of muscle, even in the case of complete tumor cure. The irradiated muscle shows a higher 18F-FDG uptake than the nonirradiated muscle. Autoradiography after eight doses (100% tumor cure) reveals elevated 14C-DG tumor uptake to be ascribable to nonmalignant cellular elements, in particular to a macrophage layer at the rim of necrotic areas. Autoradiography after four and six doses (33% and 57% tumor cure) shows the highest methionine and thymidine uptake in viable cancer cells, whereas deoxyglucose uptake did not differ between viable cancer cells and macrophages. Conclusion: To detect and differentiate viable cancer cells in a residual tumor mass after radiotherapy, PET using 11C-methionine or 11C-thymidine may have some advantages over 18F-FDG, especially if the residual tumor includes larger areas of necrosis.

    本文言語English
    ページ(範囲)280-287
    ページ数8
    ジャーナルJournal of Nuclear Medicine
    38
    2
    出版ステータスPublished - 1997 2月 1

    ASJC Scopus subject areas

    • 放射線学、核医学およびイメージング

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