Aspects of the preparation of 18F-2-deoxy-2-fluoro-D-glucose (18FDG) for medical use.

T. Irie, T. Ido, K. Fukushi, R. Iwata, M. Uoji, K. Tamate, T. Yamasaki, Y. Kashida

    研究成果: Article査読

    4 被引用数 (Scopus)

    抄録

    Fluorine-18-2-deoxy-2-fluoro-D-glucose (18FDG) for medical use had been prepared with the attention regarding radiochemical yield and purity, specific activity and quality control. More than four 18F-by-products in 18F-adducts from the reaction of triacetyl glucal with 18F2 were detected by the autoradiography of thin layer plates in which two by-products could not be perfectly removed by a column chromatography, and selective collection of the eluate gave 18FDG with the purity of 96.7% as an average in 12 runs. At end of synthesis (EOS) 259-925 MB (7-25 mCi) of a sterilized, isotonic solution of 18FDG was obtained with the specific activity of 629-851 MBq (17-23 mCi)/mg at end of bombardment (EOB) after preparation time of 3-3.5 hr, in which bacteria and pyrogen were not detected.

    本文言語English
    ページ(範囲)11-15
    ページ数5
    ジャーナルRadioisotopes
    31
    1
    DOI
    出版ステータスPublished - 1982 1月

    ASJC Scopus subject areas

    • 放射線

    フィンガープリント

    「Aspects of the preparation of 18F-2-deoxy-2-fluoro-D-glucose (18FDG) for medical use.」の研究トピックを掘り下げます。これらがまとまってユニークなフィンガープリントを構成します。

    引用スタイル