ASK1 Signalosome: A Signaling Complex Essential for Cellular Stress Responses

Kohsuke Takeda, Takuya Noguchi, Hidenori Ichijo

研究成果: Article査読

1 被引用数 (Scopus)

抄録

Apoptosis signal-regulating kinase 1 (ASK1) is a mitogen-activated protein (MAP) kinase kinase kinase that activates the JNK and p38 MAP kinase cascades. ASK1 has a broad range of biological activities including cell differentiation and stress-induced apoptosis. Recently, we have shown that endogenous ASK1 constitutively forms a high molecular mass complex, which we designate “ASK1 signalosome”. Here we introduce this novel signaling complex as a key regulator of cell fate in response to oxidative stress.

本文言語English
ページ(範囲)7-11
ページ数5
ジャーナルjournal of oral biosciences
48
1
DOI
出版ステータスPublished - 2005 1 1
外部発表はい

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Dentistry(all)
  • Biochemistry, Genetics and Molecular Biology(all)

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