Aromatase as a therapeutic target in endometriosis

Serdar E. Bulun, Khaled M. Zeitoun, Kazuto Takayama, Evan Simpson, Hironobu Sasano

研究成果: Review article査読

49 被引用数 (Scopus)

抄録

In contrast to normal endometrium, the expression of aromatase is aberrant in endometriosis and is stimulated by prostaglandin E2 (PGE2). This results in local production of estrogen, which induces PGE2 formation and establishes a positive feedback cycle. Another abnormality in endometriosis - deficient 17β-hydroxysteroid dehydrogenase (17β-HSD) type 2 expression - impairs the inactivation of estradiol (E2) to estrone (E1). These molecular aberrations collectively favor accumulation of increasing quantities of E2 and PGE2 in endometriosis. The clinical relevance of these findings was exemplified by the successful treatment of an unusually aggressive case of postmenopausal endometriosis with an aromatase inhibitor.

本文言語English
ページ(範囲)22-27
ページ数6
ジャーナルTrends in Endocrinology and Metabolism
11
1
DOI
出版ステータスPublished - 2000 2 1

ASJC Scopus subject areas

  • 内分泌学、糖尿病および代謝内科学
  • 内分泌学

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