Argifin; efficient solid phase total synthesis and evalution of analogues of acyclic peptide

Toshiaki Sunazuka, Akihiro Sugawara, Kanami Iguchi, Tomoyasu Hirose, Kenichiro Nagai, Yoshihiko Noguchi, Yoshifumi Saito, Tsuyoshi Yamamoto, Hideaki Ui, Hiroaki Gouda, Kazuro Shiomi, Takeshi Watanabe, Satoshi Omura

研究成果: Article

13 引用 (Scopus)

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An effective solid phase synthesis of Argifin, providing subsequent access to effective synthesis of analogues, was developed in 13% overall yield, as well as elucidating structure-activity relationships. The novel acyclic peptide 18b, prepared from a synthetic intermediate of Argifin, was found to be 70 times more potent as an inhibitor of Serratia marcescens chitinases B than Argifin itself.

元の言語English
ページ(範囲)2751-2758
ページ数8
ジャーナルBioorganic and Medicinal Chemistry
17
発行部数7
DOI
出版物ステータスPublished - 2009 4 1
外部発表Yes

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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    Sunazuka, T., Sugawara, A., Iguchi, K., Hirose, T., Nagai, K., Noguchi, Y., Saito, Y., Yamamoto, T., Ui, H., Gouda, H., Shiomi, K., Watanabe, T., & Omura, S. (2009). Argifin; efficient solid phase total synthesis and evalution of analogues of acyclic peptide. Bioorganic and Medicinal Chemistry, 17(7), 2751-2758. https://doi.org/10.1016/j.bmc.2009.02.047