Application of astatine-210: Evaluation of astatine distribution and effect of pre-injected iodide in whole body of normal rats

Hayato Ikeda, Yoshihiko Hayashi, Naruto Takahashi, Tadashi Watabe, Yasukazu Kanai, Atsushi Shinohara, Hiroki Kato, Hiroshi Watabe, Eku Shimosegawa, Jun Hatazawa

研究成果: Article査読

3 被引用数 (Scopus)

抄録

We proposed use of astatine-210 in preclinical study. Astatine-210 has higher yield of production and is easier to quantify than astatine-211. We produced astatine-210 with Bi target and 40 MeV alpha beam accelerated by cyclotron, free astatine-210 was separated and injected to normal rats. Three male rats (blocking group) were injected non-radioactive iodide before injection of astatine-210. Compared with the control group, the astatine-210 accumulations in the blocking group decreased to 24% in the thyroid.

本文言語English
ページ(範囲)251-255
ページ数5
ジャーナルApplied Radiation and Isotopes
139
DOI
出版ステータスPublished - 2018 9

ASJC Scopus subject areas

  • 放射線

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