Apoptosis of Lymphocytes in Mice Administered Lipopolysaccharide from Leptospira interrogans

E. Isogai, H. Isogai, T. Kubota, N. Fujii, S. Hayashi, T. Indoh, S. Takagi, H. Miura, K. Kimura

研究成果: Article査読

14 被引用数 (Scopus)

抄録

We report that administration of leptospiral lipopolysaccharide (LPS) in mice results in massive surface marker changes in the lymphocytes of the spleen. It appears that many of these changes relate to the large number of cells undergoing apoptosis. It is also shown that tumor necrosis factor-alpha (TNF-α) induces similar effects and is produced in large quantities after injection of leptospiral LPS. It is likely that cytokines such as TNF-α are involved in apoptosis.

本文言語English
ページ(範囲)529-537
ページ数9
ジャーナルJournal of Veterinary Medicine, Series B
45
9
DOI
出版ステータスPublished - 1998 11

ASJC Scopus subject areas

  • 医学(全般)

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